you in section: Functional infringements
Patogenez of radiation injuries of kidneys is not absolutely clear.
Functional infringements the Ionizing radiation leads to liberation from cages gialuronidazy, which depolimerizuet mukopolisaharidy therefore permeability of membranes raises.
In a sharp stage of a beam nephrite korkovyj the layer of kidneys is expanded, are found out in a hemorrhage considerable quantity. At microscopic research primary defeat of capillaries klubochkov and stromy, and also arteriol comes to light. In a capsule gleam klubochkov accumulates ekssudat; kanaltsevyj epitely bulked up, it is torn away in a gleam kanaltsev. With the help gistohimicheskih researches heavy infringements nucleinic, lipidnogo and a carbohydrate exchange come to light. In the subsequent develops fibrinoidnyj nekroz loops klubochkov with the subsequent smorshchivaniem and gialinizatsiej separate klubochkov.
At electronic microscopy find out disorganisation of endocellular structures, a degeneration epitelija, mainly proksimalnyh kanaltsev. During the remote period (later 6-8 mes) dystrophic changes epitelija izvityh and straight lines kanaltsev, a circle-lokletochnaja infiltratsija with fibrinoznoj reaction remain. nefroskleroz 8-14 years after an irradiation can develop later.
In case of incorporation of radioactive substances in a nephritic fabric nefroskleroz develops faster (through 1 — 2 mes).
As a result of sharp or chronic influence of beam energy arise functional libomorfologicheskie changes in kidneys, as defines clinical semiotics.